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Keep throwing P0300 code (Multiple Cylinder Misfire)


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Ok, so here's the deal my truck keeps throwing the P0300 code (multiple cylinder misfire) and we can't figure out what is wrong with it. We've changed the knock sensor, the crank position sensor, changed the whole distributor to a MSD billet distributor (street fire model), changed plugs and wires, changed the coil. None of them have changed the fact that it keeps throwing this code. I also have the upgraded acdelco Spyder injection system. The motor is a freshly built 383 stroker built by a reputable engine builder when we first started the truck it ran like shit so we sent the computer to blackbear and had it tuned to the motors specs. When we got the tuned computer it in the truck it ran a hell of a lot better but it still keeps throwing this code. If anyone can point me in the direction of what could possibly be wrong or point me towards a good tech for these truck it would be greatly appreciated.

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