Mark l day

I have a 2001 chevy silverado 1500 with the Ls 53 v8 and I have been getting a misfire code for the last 2 moth First, it started out as a multi cylinder misfire to cylinder 5 misfire. And I've changed Fuel injectors, spark plugs, and wires. After changing all that, it went from the cylinder 5 two cylinder 8 misfire And if I unplug my. Mass air flow sensor the cylinder 8 in the spirit goes away. And I also changed the coil to see if it would change. And it still misfire