2018 Sierra Denali Extreme
I had the same issue. I was gone for 10 days and upon return used my remote start option to ensure my battery was still charged (it was) and let it run until the automatic shut off after 15 minutes. Later I went out to get something out of it and the dreaded 3 horn honk happened (all 4 doors)
I check online and the only thing I found was someone that said "it stopped after about 12 hours time".. Mine didn't, so I called the dealer today. Quote: "Never heard of that, unless the key fob is in the truck" (it wasn't) Was told to bring it in. Went out to my truck and low and behold it has stopped after 24 hours. Thank goodness! It was so annoying to me and my neighbors. Of course now when I bring it to the dealer for service it won't be doing that, so my only thought is that it may have something to do with the auto start feature.... but who knows?!! Anyway it's stopped for now!