Just made a 358 mile round trip from Fort Worth to Norman, OK and back, through wind (headwind / crosswind / tailwind), mountainous terrain in the Arbuckle mountains, and flat land. This was on a 2nd straight tank of E85, with the cruise control set on 75mph the entire way, with very minimal (3-4 miles) town driving. I averaged 17.8 mpg on the DIC trip readout. My last trip from Fort Worth to Lubbock and back I averaged 22mpg on premium unleaded. The mileage is definitely better (about 25-30%) with unleaded, but you can feel a difference in power with the E85. I'm 100% stock 2wd crewcab, 20" texas edition wheels, 5.3 and .342 gears.