I realize this is an old thread but for those buying used 2017 like me, the big, big difference is the max tow package, as mentioned above. It is a bit of a unicorn but if you see a 2017 or 2018 with the 2500 towing mirrors, it probably has the max tow package. That puts towing capacity at 11,700 pounds on a crew cab 4wd while the Denali cannot be configured above 9,100 pounds. So that made ALL the difference for me. It meant I didn't have to buy the used 2500 for $20K more...and get the jolting ride of a 3/4 ton. Pulling a 7,000 pound trailer (dry weight) means the Denali wouldn't cut it once I was loaded up.