I have a 2021 Denali 1500 and just started experiencing the same problem. Had to have the lifters replaced at 14k miles, 36k miles a rattling/ popping noise started coming from the rear end of the truck when reversing or turning on inclined surfaces, and today at 41k there’s the humming sound from the AC and now only one of the rear vents works. I never thought I’d experience this many issues buying a brand new truck.