Its been a while since I posted so here's an update on my 06 Sierra:
engine: 5.3 with 3.73 gears, (tow package)
I've replaced: O2 sensors, knock sensors, evap solenoid, brakes, tie rods. There's probably more but can think of it now. With only 130,000 miles its been a very reliable truck. I have some burned out lights on the radio and climate controls that bug me, but not enough to replace them yet. It has the intermediate shaft clunk, but as long as I disconnect it every 12-24 months and move it back and forth for a few minutes it goes away.
I am planning new plugs, wires, trans filter and fresh oil for transfer case/front and rear axles within the next month or so.
The rockers and door seams are getting rusty so I'm going to need to give them some attention as well soon.
My other vehicle is a 2011 Tdi which I love but VW's offer to buy it back is too good to turn down. I'm trying to justify buying another GMT-800 to replace it, but the reasonable part of me is saying I need 2 trucks like I need a hole in the head....