My Silverado is a 2018 crew cab with a 5.3 6spd transmission and 155,000 miles I haven’t any problem with lifters or transmission. I experienced the “ Open and close driver’s side window” message for a bad ground wire connection.
I have a 2018 Silverado LT which had a 3” rake and used a 2” front end lift by Moto Fab. I run stock 17 wheels and Yokohama X-AT 265/70R17 OW:10.50.
Next tire change I will go to 275/70.