I am looking at the same questions for my 2011 5.3. I found some youtube videos which indicated 219/223 durations and 600/600 lift at LSA 114 for LS trucks was the "ultimate" 5.3 LS upgrade. In fact two different youtubers said about the same thing. The problem I have with researching all this, there are always issues left out by different youtubers. My build will be strictly street. I want to keep my low end torque and not get too much past 6000 rpm. I will need to delete DOD/AFM like you. Also the relatively small rear end gears ( I am not sure what I have now but I want to go to at least 3.90) will require differential work. Besides all the replacement parts in replacing the cam - lifters, push rods, rockers, etc, I feel I need to upgrade the 6L80 transmission.
With all that said, I found the attached Summit PRO LS Cams document that has a Stage I cam at 205/217 500/500 112 and Stage 2 cam of 218/227 600/600 112. The second one seems to fit the youtubers I saw. I don't think I want to get into Stage 3 or 4 and replace the torque converter.
Good luck with your research.
Jim
img001.pdf