This just happened to me while listening to XM radio in my brand new 300 miles 2022 Sierra 1500. Scared the ****** out of me. The Bose speakers pack a serious punch at max volume! Volume dial and Power/Mute button were non responsive. I was able to select a new audio source (i-phone) on the right steering wheel dial and bring it back to normal.
I strongly encourage anyone having this issue to file a NHTSA report via the website. Its the only way to get GM's attention and open then up to liability if someone gets hurt. My report number is 11524368.
Link to report via NHTSA:
https://www.nhtsa.gov/report-a-safety-problem#index
I found a similar issue TSBs on the 2019 Sierra
https://static.nhtsa.gov/odi/tsbs/2019/MC-10170421-9999.pdf
https://static.nhtsa.gov/odi/tsbs/2020/MC-10183183-9999.pdf
If anyone finds a solution please keep us posted.
Thanks!