I know my evo9 was not flex fuel and had to upgrade injecters and adjust tune to get scaling and afr correct for e85. E85 is like steroids on evos and for silverado i have only noticed minor gain so far witout a tune.
For the silverado since mine is flex fuel i believe it adjust the afr for e85. For non flex truck, i would strongly recommend tune for it. I am new to silverado so i don not know if your afr will automatically adjust to e85 without a tune. I wont gamble with that unless i knew for sure.