285/65r18 : No rub except maybe a little on swaybar.
295/65r18 : Might rub a little on swaybar and liner. Very few tires available in this size.
295/70r18 : Will rub swaybar and liner. Really need 4" total lift for this tire.
Even if the wheelwells look level, the big hoods on these trucks make the nose look high if you don't put the rear block in. Put 2" up front, and you lose all the rake, at least visually. If you never put anything in the bed, you might like the look, but carry or tow anything, and you will wish you put the rear block in. There are hundreds of leveled pictures on this site and others, so it's a choice you are going to have to make for yourself. Google Images: Leveled Silverado
I have a friend running a 2015 with that exact tire with the full RC 2.5" level (front and rear) on Fuels 20x10 with 0 offset. He is rubbing the liner bad in reverse lock. You want to push the tire out 1.78" which may help you with the liner rub, but might cause you issues with the fender.