I am rarely on the interstate but on a lot of 55mph two lane roads in TN, VA, NC which are rarely flat. This truck pulls them just fine but only 1.5 mpg better than my 2002 which had more ground clearance and heavy LT tires with 4.10 gears is kind of sad IMO. I've got 6,000 miles on mine so it is pretty much broke in. Gas mileage is not a huge concern for me but with reduced ground clearance, lighter materials, street tires, direct injection, and cylinder deactivation I expected more. My work truck is a 2012 Ford F150 with a huge brush guard and winch (3.55 gears) and when it had "AT" street tires on it I was getting right at 20 mpg in the summer, and this is from a truck without the fancy fuel saving gimmicks. I've got heavy LT tires on it now and I am down to 17.5 mpg in the Ford.