A few observations about my truck's vibrations:
They seem to be worse with higher psi in my 10 ply tires.
Once they get going at high speeds, it is hard to get them to stop and it feels like it is going to vibrate me off the highway.
I've tried with the rear leaf spring clamps, can't say definitively whether it has helped.
Anything messing with the suspension in the rear temporarily helps it. For exam, I have the Firestone Ride Rite air bags in the back. If I inflate them and raise the back of the truck, it rides without vibrations for several miles, but then they come back. If I let the air out and lower it back down, I have the same thing - no vibrations for a while and they they come back.
They seem to be less severe in turns.
Most of the time they are better if I keep it in M5 and tow mode, although they are still there. I can't figure out if the engine is unbalanced at low RPM's, or if the higher RPM's at a given speed are helping to counteract or balance out the harmonic vibrations.
I've owned several GM trucks before. My last one had 200k+ miles and drove much better than this one drives now. I was aware of the vibrations in 2014's before buying my 2015, and test drove it extensively on the highway. It was smooth as glass for the first 1500 miles.
The dealers have been pretty much worthless. I can't get them to return my calls, and when I drop it off they do almost nothing except drive it and say it is operating as normal. The last dealer said it definitely had the vibrations, but that they aren't getting enough money from GM to make it worth their while to work on these trucks. They have had several of them with no resolution. On the service write up, he blamed it on my aftermarket tires and leveling kit, even though I clearly brought it in with the same problems prior to new tires and leveling kit.
This problem, and GM's lack of acknowledging it, are causing me to consider other brands for the first time. I have been very GM-loyal customer but this is all changing. My wife was in the market for a Yukon Denali but is now looking at Infiniti's, Toyota's, etc. I'm now looking at F-150's if I can't get the ride problem resolved.