I would have to say that the V4 mode definitely helps, atleast in my setup. I work 347 miles from home and I make the drive up to 2 days a week. Every time I get my truck on the road it is for the long haul. If I set the cruise below 73mph my V4 mode will regularly kick in and will hold this in less I am going up a hill. Granted my truck is turning 2250 rpm at this speed. Cruise set at 73 I can get up to 17.6 mpg. At 75 mph 4 cylinder does not kick in except down hill and I am at 15 mpg. I have thought about tuning it out but as much highway driving as I do I have decided not too yet. Set the cruise at 65 and 4 cylinder mode will stay on 85% of the time and I will get close to 19 mpg. I can watch the little fuel economy bar and tell when it is going to shift. Below 17 mpg and it is in v-8, 17-18 mpg and it shifts into v4. Once it is in v4 it will stay in till I pull the mpg readout down to 16 with the skinny pedal and it will shift back to v8. This is with 6" lift, 35 " tires and 4.56 gears. I would love to take a trip and keep it at 65 just to see what it would do but I don't have the patience as that will add another 40 min to an already boring drive.