By accident, I did a search on my Diablo i3 tuner and found it has a 'Flex fuel' tune in addition to the 87, 91 and 93 octane gas tunes. So, I filled with Ethanol twice (currently, about 65% ethanol per my Diablo sampler) and tuned it for Flex. I added a slightly firmer shift (trans is too sloppy and I'm always pressing harder to push it along and now happier since the new tune... I still press the go pedal but for better reasons) and ensured the DOD/AFM is OFF. Overall, no noticeable change other than the better shifting. But, it is early and I hope to enjoy it regardless.
NOTE: I'm not concerned with mileage as I am WFH since March 2020 due to the 'lockdown' and my once-weekly 1-hour drive each way (beer and wings with my buds) is my one long trip I get to enjoy listening to the flowmaster Force II exhaust note.
I am tuning now for enjoyment. Also, I am looking seriously at potential for delete of DOD/AFM due to my 70K mileage... a separate thread/topic.