I'd recommend it. Its very useful. I already had a bunch of stuff under neath my rear seats so I moved it to the truck bed for some additional storage. Such as some tools, tow straps, etc.. The little tray is also very helpful for tape or glue.
No concerns, Just measure twice, or even three times. I would recommend using a drill.
What I did was is use one screw on the back plate and then one screw for the other bracket. PS if you notice on the black plate, there is a black plug that you line up to an existing hole in the truck bed (this is the starting point). Made sure they lined up and the box opens and closed without any issues. Then tighten those two bolts and then do the other 5 bolts.