Diesel or gas?
The 37s will obviously, drastically reduce mpg, but the gasser will take a bigger hit to mpg, and power.
Rough guess, but I'd estimate at least a 2mpg hit on the diesel, and up to 4on the gasser. Maybe more.
I wouldn't sweat a gear change on a duramax at all, and unlikely on the gasser either. You're obviously not concerned with acceleration or towing, and the 10spd will find itself in the right gear without much hunting, if any.
If towing, mpg and acceleration are a concern, you're doing the wrong mods.
Either leave it alone, or do the lift/tires and let the chips fall where they may.