The advantages of the tune for me are; I live at 7200ft elevation. Everything I do in Colorado is at 9000-11000 ft. Hunting, ATVing, camping. With the factory already holding back my crank rated power at less than full throttle, every bit of usable power is desired especially sine those activities involve pulling a trailer into the mountains. The other plus is the drivability of the transmission. Soft pedal input, soft shift. Heavy pedal input, firmer/quicker shift. Those two things are actually good for the transmission as it applies more power. My torque curve do to the ajustment in power enrichment also makes it respond better to moderate throttle input. Meaning I can pull away from a dead stop with a load better.
Last thing on E85 vehicles. While it generates similar power to what I have now, the factory tune is still holding a portion of that in check in the name of protecting the drivetrain. My set up is not.
I have had zero issues with warranty on my previously tuned GM products. As others have said, it would need to be verifiable the tune was the culprit. At this level of minimal modification, and the over engineered strength of the LS motor, 6L80 trans and drivetrain, easily exceptable risk.
Cheers