I'm going to start the crazy train. Unfortunately, it's rooted in GM history. Whatever the Corvette got the trucks got, but detuned for less horsepower and torque so the torque would come on stronger. 99% of parts comes from the parts bin. Therefore, here's what I am guessing will happen.
2.7 turbo 4 with 8-speed
It's the base engine and replaces the 5.3
3.0 Duramax with 10-speed
Stays! Maybe GM makes a few tweaks to make it marginally better.
6.2 with 10-speed
Yes, it's the same block as the 5.3, but it commands a $2,500 premium. GM lives profit and profitability. No increase in power output, and that means this engine is no longer the top selection in the order guide.
5.5 flat plane with 10-speed
GM needs a 500 bhp engine. The 10-speed demonstrated it can handle the power output on the Camaro ZL1. Can you imagine the exhaust sound? I can't because GM will muffle it with baffles. It will be slightly detuned for decreased bhp and btq so it doesn't rain on the Corvette Z06's parade. Engine would be tuned for lower peak torque value. Smaller displacement may mean lighter weight truck, which means improved mpg. And, if you want forced induction it's available, but you gotta do it yourself just like how people are currently mounting the supercharger from the LT4 onto the 6.2 in the Silverado. Twin turbos and 1,000+ horsepower!
Wishful dreaming
A hybrid. GM has played in this arena before, but bailed right before bankruptcy. Ford nailed it with their hybrid F150, imo. I think it's called Powerboost. Due to the tiny gas tank on the current V8 gassers I could see that remaining space on the drivers underside filled with batteries. I'm not talking something like the Toyota Tundra hybrid system that's not really about extending range. Look to Ford and make it comparable/better.
How that for crazy?
I don't see GM installing the 6.6 gasser in the 1500s. Iirc, it's a heavier cast iron block instead of aluminum. Sure, the block can handle 1,000 bhp, but it's pointless for a truck where mpg matters to the consumer. Lighter is better.