When I worked (retired now) and drove 70 miles a day, my average was 22mpg. Strictly 93 octane too. I couldn't have been happier. Now that I barely put 2,000 miles a year on my truck, I have opted for E85 for no other reason that price. MPG isn't all that critical to me anymore, plus the fact I can go across the border to Ohio and pay as little as 1.83 per gallon. With E85 my mpg is normally around 16. Big difference, but so what. I'm am not a lead foot either, but the noticeable power factor running E85 is pretty cool too.
I have no doubt, if I go back to 93 octane, my mileage will go right back to what it used to be. I love the fact too, my truck is a bit over 4 years old now and at barely 40,000 miles, it's still barely broke in.