My expectation for any vehicle:
250k on the original engine and transmission. Following manufacturers recommended maintenance. (I know, another argument)
After that, there's not much truck left around them.
Weather: faded paint, dried out rubber and plastic, hazy headlights
Urban/Rural warfare: Door dings, rock chips, brush scratches, windshield chips, fender benders
Road wear: CV-shafts, ball joints, wheel bearings, bushings, water pumps, seals and gaskets
Kids: Stained seats, carpets, melted crayons
Oops: Got in with a screwdriver in my pocket, knocked something over in the garage on it, left the windows down in the rain...
It's a long road (pun intended) to keep a vehicle nice enough to continue investing in after the 10 years/250k miles.