The main difference is: stiffer frame, beefier rear differential, slightly heavier suspension, not just over loads, springs sway bars etc, and beefier brakes.
i have a 2020 3500hd SRW and find the ride quality on an empty truck. Ive had several dualies and wont own another one and i tow 4 days a week, there great on the interstate with a heavy load. Their a pain in cities, also if you spend anytime on dirt, mud, wet surfaces, grass they have poor traction unless loaded up, and the ride is really stiff empty.