I know it's not a Denali, but on my Silverado LTZ, I first added the Bilstein 6112's front for leveling, 1" block and 5160's in the rear. With the factory rims and tires, the ride improved greatly over the factory ride. Recently, I added new tires and wheels, and the ride suffered. Not terrible, but not what it was with the Bilsteins and Factory wheels/tire combo. Going to an LT rated tire makes for a stiffer ride.
But after a few weeks, I do not notice the ride difference. I do highly recommend the Bilsteins.