Random Misfire, No Cruise, P0300, 2004 6.0v

[389sixpack]

So searched a bit, found some post. Runs like a vacuum leak. CEL comes on solid, flashes every now and then. Checked for Vac leaks but none found. Some one said clean MAF sensor and clean replace O2 sensors? Would the P0300 effect the cruise control? Or will PCM default Cruise off if there are codes coming up? If some one has been here before, give me a few ideas what may be a culprit. Thanks

[Nytemare]

I have heard a few guys saying that some model years have bad intake gaskets. That will cause a Vac leak

 

The PCM should kick you out of cruise when you get a P0300, Random/Multiple Cylinder Misfire Detected.

 

Could also be a bad crank position sensor or a faulty knock sensor.