If there was some kind of "inherent design flaw", there would be WAY more posts about replacing fuel pumps. I replaced my fuel pumps (I have 2 tanks) 4 years ago, haven't had a problem with them since and I've put on 100k km since then. I think my main, important pump (the one in the front tank, pumping to the engine) is an Airtex, but my system is also a returnless style, so it's different from yours.
I would say it's more likely that there is some specific problem with your truck, such as it generates too much vacuum in the tank, or an electrical problem, or the pump has to work to hard because the FPR is faulty, or maybe something else.
And is this 3 pumps since 2000, or your 3rd pump in say, 5 years?