Not knowing the history on who is putting in these transmissions and how you drive the truck, some of this could be self inflicted. Like if you put in used transmission or you had a "shop" do rebuilds for you. Always use a GM transmissions or buy a built transmission from a company with skin in the game. Also never run the stock 6L80e converter again, get a billet torque converter that won't break like the stock units do.
And to answer the manual question. Sure, anything is possible but good luck making it work. You can convert it to manual but you're going to spend way more money, way more time and you better know what you are doing. These trucks never came with a manual, so nothing exists as far as swap in and go parts. You'd be piecing it all together from various manual transmissions from cars. Then you have to figure out how to make the truck happy now that it doesn't have an automatic transmission anymore. Can't really just tune it when that combo never existed, so you can't just change the calibration file to make it work.