1999 k1500 half ton 5.7 suburban, #2 misfire

[paulokeefe]

Truck ran fine, did a tune up, oil, oil filter, spark plugs, wires. Ran perfect. Had a cold snap at -5 degrees outside an out of no where I have a misfire in the #2. Checked gaping, got a new set if wires and replaced distributor and rotor. Still reading misfire. I also put HEET in the gas..still no luck..have not gone to shop yet..already spent a couple hundred replacing everything twice..can anyone PLEASE give me advice

[Jsdirt]

My first thought is an air leak thru the intake manifold gasket around that cylinder. A colder-than-usual engine will contract a bit more & allow a larger-than-normal leak. Do the carb cleaner trick & see if you notice a change in RPM. If it rises, the solution there would be new intake gaskets.

[jaredlucky16]

Bad injector Think that has that problematic spider injection