Can a cylinder 2 misfire be a lifter if not d.o.d.?

[bensaccount]

We have a 5.3 misfire on a non displacemtn on demand cylinder #2 that we cannot fix. Is it possible that it is a lifter if it is not d.o.d.? We have tried everything and don't want to change lifters and find out it does not solve anything.

[rdnkcpa]

Cannot fix as in a misfire on #2? Is the lifter clacking? Did you do a compression check? Did you have a lean code at any point? How many miles on the engine? Do you have any other codes? If you don't have lifter noise, check compression. A couple of possibilities can be a leaking head gasket or burnt valve. Fuel injector good?

[Dnt]

Well if you have done everything then you are done. Probably best to just drop in a new long block. Pace performance and several others regularly run specials on rebuilt 5.3s around 3k BAM done. I guess it is according to what truck you have (might be a 500 dollar beater LOL) but for 3 grand it might be worth a look.

http://www.powertraindirect.com/engines/gm-5-3-crate-engines/?keyword=5.3%20Crate%20%2Bengine%20For%20Sale&gclid=COX8ldinv9ACFZM2gQod534Eig

[bensaccount]

135k miles, spark, coil, smoke test good, literally every test done. When you drive it it drives good and then suddenly starts shaking and driving rough with a cylinder 2 misfire. Compression is down when this happens otherwise good. Appears to be some minor scratches in the offending cylinder not found in cylinder 4.