Dash instruments and other electronic stuff stops working while driving

[Chad Golden]

I have a 2010 silverado and am having problems figuring out why while driving the dash instruments, radio, power to windows, and control to the AC stops working I have replaced the ignition switch and thought it fixed the problem but a month since I changed it and it seems to be worse then before 

[sefiroxx]

Probably loose or corroded ground.

[Colossus]

99% sure you have a ground issue.  I'd give the negative battery cable a good over and work your way from there.  Had this issue on a 07 Sierra.  Was very random and dealer could not figure it out by the time I got rid of it.  But lots of others on here posted similar issues and the negative battery cable was the place to start and for many fixed the issue.