Traveling to San Fransisco, need idea's

[Black02Silverado]

We are looking at taking one last family vacation this coming March to San Fransisco. Our one daughter will be graduating college in May and once she is out and on her own with a job it will be harder to go on one. We have a special needs daughter as well and so need to find a good location in SF that we can get around easily with a wheel chair. From what I have read SF is very handicap accessible. We like to find a place to stay that we can walk to most of the sites. I know some are not that close but was wondering if anyone has any ideas?

Would staying closer to Fisherman's Wharf be better than city center? We did see that we can get a full day of sight seeing to Napa Valley, transportation to and from which is good.

We will be flying from the east coast so a direct flight is 6hr and at least we only loose 3 with the time change so we can make the most of the first day, but will loose that coming home.

So anyone have suggestions as to what to see while we are there for a week?

Is Trip Advisor a good source?

[Colossus]

No advice here, as I'm not good with cali except avoiding it most of the time - however- you have a SPECIAL daughter.  Not a special needs.