According to the order guide:
2020 2500 Denali:
U1D In-vehicle Trailering App, System, includes checklist, trailer maintenance reminders, trailer security alerts, trailer mileage, tow/haul reminder, trailer electrical diagnostics and Trailer Tire Pressure Monitor System module
SLE - Included and only available with (ZL6) ProGrade Trailering System or with (PDQ) Preferred Package. Includes trailer tire pressure monitoring alert ONLY when (PTT) trailer tire pressure monitor system is factory ordered and sensors are installed
SLT - Includes trailer tire pressure monitoring alert ONLY when (PTT) trailer tire pressure monitor system is factory ordered and sensors are installed. With (ZW9) pickup bed delete no provision for a trailer tire pressure monitor system will exist but all the other (U1D) features will remain.
AT4 and Denall - Includes trailer tire pressure monitoring alert ONLY when (PTT) trailer tire pressure monitor system is factory ordered and sensors are installed
Base sierra -- not available
PTT Trailer Tire Pressure Monitor Sensors, includes set of 4 sensors. Sensor functionality requires (U1D) In-vehicle Trailering App to be ordered with the vehicle and installed by the factory. Sensors will be shipped loose with the truck and will need to be installed on trailer by customer. System is capable of monitoring up to 6 wheels. Additional or replacement sensors are available through GM Accessories
SLE - Requires (ZL6) ProGrade Trailering System or (PDQ) Preferred Package. Not available with (ZW9) pickup bed delete.
SLT - Not available with (ZW9) pickup bed delete.
Optional, but no restrictions on AT4 and Denali
Base sierra - not available.
Seems like trailer tire monitoring may not work if PTT sensors weren't factory ordered.